-NQO 유도 백서 혀암 발생과정에서 L-type Amino Acid Transporter 1 (LAT1)과 4F2 Heavy Chain (4F2hc)의 발현
윤정훈,
소속 상세정보
윤정훈 ( Yoon Jung-Hoon ) - 조선대학교 치과대학 병리학교실
KMID : 0829220090330050245
Abstract
Amino acid transporters play an important role in supplying organic nutrient to cells. The expression profile of L-type amino acid transporter 1 (LAT1) and its subunit 4F2 heavy chain (4F2hc) on different differentiation stages in 4-NQO induced rat tongue carcinogenesis was examined using immunohistochemical analysis. The gradually increasing LAT1 and 4F2hc expression detected during the multistep progressive change shows that the protein may have an important role in the multistep tongue carcinogenesis. Conclusively, LAT1 and 4F2hc can be a useful biomarker for a better understanding of multistep tongue carcinogenesis, while the specific inhibition of LAT1 and 4F2hc would be a new rationale for suppressing tumor cell growth in tongue cancer.
키워드
LAT1;4F2hc;Tongue carcinogenesis;Biomarker
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